Endocrine Abstracts

Introduction: Prolactinomas are the most common of functional pituitary tumors. Dopamine agonists are the first line treatment of prolactinomas but have antagonistic effect with antipsychotics (dopamine receptor blockers) used in schizophrenia. The association between these two illnesses is a medical challenge, as the treatment of one disease can exacerbate the symptoms of the other one.Clinical case: We report the case of a 72-year old man, newly diagno...

Introduction: Pituitary stalk interruption syndrome is a rare disorder characterized by a specific tirade: an absent or hypoplastic anterior pituitary gland, thin or absent infundibulum, and ectopic posterior pituitary location. This syndrome has been described in association with other somatic abnormalities and recently a polygenic etiology has been suggested. Herein, we report a case of type 1 diabetic patient, explored for short stature, revealing a pituitary stalk interrup...

Introduction: Growth hormone deficiency (GHD) is a rare cause of delay of growth. However, it is primordial to screen for it since its presence leads to a specific treatment which improves statural prognosis. GHD should be confirmed through stimulation tests such as Insulin Tolerance test (ITT) or Clonidine Stimulation Test (CST). The objective of our study was to compare these two diagnostic tools.Methods: We conducted a retrospective study in the endoc...

Introduction: The use of GH treatment in patients with macroadenomas and GH deficiency is of concern to the clinician due to the theoretical stimulation of tumor regrowth by GH substitution. We report the case of an 18-year-old adolescent with a macroprolactinoma causing delayed stature and puberty.Observation : We report the case of an 18-year-oldadolescent who consulted for gynecomastia with delayed stature and puberty. Physical examination displayed a...

Non-secreting pituitary adenomas (NSPA) are relatively rare benign tumors their prognosis depends essentially on their endocrine and ophthalmological repercussions the aim of our study is to outline their clinical, biological, radiological aspects, and the therapeutic choice.Methods: Retrospective study of 17 patients with non secreting pituitary adenomas.Results: We identified 17 patients with NSPA split into 12 women and 5 men wi...

Introduction: Primary hyperparathyroidism (PHP) is the result of excessive, independent, and inappropriate production of parathyroid hormone (PTH). The aim of this work is to study the epidemiological, clinico-biological and therapeutic aspects of PHP.Materials and methods: This is a retrospective study of 34 patients hospitalized for the management of PHP in the Endocrinology Department of the Military Hospital of Tunis between March 1999 and July 2018....

Abstract: Brown tumors also known as osteitis fibrosa are a very rare complications of primary hyperparathyroism that occur in less than 2% of patients suffering from any form of hyperparathyroidism. Parathormone increases osteoclastic activity in the bones causing cystic bony changes, it’s a reparative cellular process. Common sites of brown tumor are the ribs, clavicle, long bones and pelvic girdle. Our case is 55 years old tunisian men who was admitted to orthopedic de...

Introduction: The ectopic posterior pituitary is a rare condition which is characterized by the ectopic location of posterior lobe of pituitary, pituitary stalk abnormalities, and associated clinical manifestations of anterior lobe related growth hormone dysfunction or less commonly multiple anterior pituitary dysfunctions. We describe the case of a young female who presented with short stature and was found to have ectopic posterior pituitary.Case prese...

Background: Multiple endocrine neoplasia (MEN) are rare and are characterized by the association of a neoplasia or hyperplasia of at least two endocrine glands. Rare cases of atypical MEN were reported in the literature. We describe a rare combination of acromegaly, papillairy thyroid carcinoma and primary hyperaldosteronism.Case presentation: We report a case of a 48-year old woman operated for papillary thyroid carcinoma. Five years later, sh...

Introduction: Androgenic insensitivity syndrome (AIS) is an X-linked genetic disease characterized by resistance to the actions of androgen in an individual with 46, XY karyotype. It is the most common cause of DSD in 46, XY individuals.Case report: We report a case of a 16-year-old girl who consulted for primary amenorrhea and hirsutism. Our patient had a 9-year-old sister who was operated for an inguinal hernia and the anathomopathological study conclu...